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Convalescent plasma therapy in the management of COVID-19 patients and its effect on morbidity and mortality
Madhav Prabhu1, Harpreet Kour2, Shivani Charuhas Bhagwat1, Akash Ramaswamy1, Arathi Darshan1, Jayaprakash Appajigol1
1 Department of General Medicine, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India
2 Department of Physiology, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India
Correspondence Address:
Harpreet Kour,
Department of Physiology, Jawaharlal Nehru Medical College, Belagavi, Karnataka
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/bjhs.bjhs_171_22
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BACKGROUND: Since the beginning of the COVID-19 pandemic, there have been preliminary studies worldwide, hoping to shed some light on the efficacy of convalescent plasma therapy (CPT) in the management and recovery of SARS-CoV-2-infected patients. There is a dearth of such studies, especially from one of the world's second-worst hit country-India. This study aims to determine the effects of CPT on the clinical and biochemical profile, and overall mortality of patients suffering from moderate-to-severe SARS-CoV-2 infection.
MATERIALS AND METHODS: After random selection of inpatients with COVID-19 disease, patients were matched for various characteristics and allotted into cases and control groups. This was done keeping a 1:2 ratio for cases and controls. Cerebral palsy (CP) therapy was administered to only cases, and these groups were compared. P < 0.05 was considered statistically significant.
RESULTS AND CONCLUSIONS: Totally, 141 patients – 47 cases and 94 controls – were compared for the efficacy of CPT on clinical and biochemical profiles along with mortality benefit. It was found that CP therapy provided no significant morbidity and mortality benefit.
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